主演威尔·史密斯并不经常出现在这类文艺片中，此次是受到改编自真实传记的剧本打动，才决定出演男主角，并亲自担任制片工作，他还找来以《冲击效应》走红的黑人女星谭蒂出演。因为非常欣赏加布里尔·穆奇诺导演的电影《最后一吻》和《同床异梦》，威尔·史密斯邀请加布里尔·穆奇诺来执导这部电影 。
《当幸福来敲门》台词
1、有了目标就要全力以赴。
When you have a goal, you have to go all out.
2、如果你有梦想，就要守护它。
If you have a dream, guard it.
3、当人们做不到一些事情的时候，他们就会对你说你也同样不能。
When people can't do something, they'll tell you that you can't either.
4、如果我雇佣了一个没有穿着衬衫走进来的人，你会怎么说？
What would you say if I hired someone to come in without a shirt on?
5、你要尽全力保护你的梦想。那些嘲笑你梦想的人，他们必定会失败，他们想把你变成和他们一样的人。我坚信，只要我心中有梦想，我就会与众不同。你也是。
You have to do your best to protect your dream. Those who laugh at your dreams are bound to fail. They want to make you like them. I firmly believe that as long as I have a dream in my heart, I will be different. you too.
6、我坐在那儿半个多小时一直想编出个故事来解释为什么我到这里却穿着这身衣服，我想编出个故事来证明我拥有你们所期待的品质，比如诚实勤奋团队精神等等，但我什么也没能想出来。事实上我因为没有付清停车罚款被拘捕了。
I've been sitting there for more than half an hour trying to make up a story to explain why I came here wearing this dress. I want to make up a story to prove that I have the qualities you expect, such as honesty, diligence, team spirit, etc., but I can't think of anything. In fact, I was arrested for not paying my parking fine.
7、他一定穿了一条很棒的裤子。
He must be wearing great pants.
8、幸福里面没有为什么，只有我。
There is no reason in happiness, only me.
9、当你最认为困难的时候，其实就是你最接近成功的时候。
When you think it's difficult, it's when you're closest to success.
10、别让别人告诉你你成不了才，即使是我也不行。
Don't let people tell you you can't make it, not even me.
11、不要让别人告诉你，你不能做什么。只要有梦想，就要去追求。(cnhbtc.com)那些做不到的人总要告诉你，你也不行。想要什么就得去努力，去追求。
Don't let people tell you what you can't do. As long as you have a dream, you should pursue it. ( cnhbtc.com ）Those who can't always tell you, and you can't. If you want something, you have to work hard and pursue it.
12、也许幸福是一种只能让我们不断追寻的东西，而却无法真正拥有…………
Maybe happiness is something we can only pursue, but we can't really have
13、我就是这样一种人你向我提问如果我答不上来我就会告诉你‘我不知道’但我保证我清楚该怎样找到答案，我会找到答案的”面试官说“假设有个人不穿着正装就跑过来面试然后我却录用了他，你会怎么评价？
I'm such a person. If you ask me a question, if I can't answer it, I'll tell you "I don't know." but I promise I know how to find the answer, and I'll find the answer. "The interviewer said," suppose someone came to the interview without formal clothes, and then I hired him. What would you say?
14、主，不要移开那座大山，请给我力量爬过他。请不要移开那些绊脚的石头，在任何时候指引我，主。我的负担很重，好像很难承受，但是我不会放弃。因为你向我许诺答应了。而且你已经满足了我在圣坛前的祷告。
Lord, don't move that mountain, please give me strength to climb over it. Please don't remove the stumbling stones and guide me at any time, Lord. My burden is heavy, it seems hard to bear, but I will not give up. Because you promised me. And you have satisfied my prayer in front of the altar.
15、如果你有梦想的话，就要去扞卫它。那些一事无成的人想告诉你你也成不了大器。如果你有理想的话，就要去努力实现，就这样。
If you have a dream, go guard it. People who have done nothing want to tell you that you can't make a big deal. If you have an ideal, try to realize it. That's it.
16、我是这样的人，如果你问的问题我不知道答案，我会直接告诉你“我不知道”。但我向你保证：我知道如何寻找答案，而且我一定会找出答案的。
I am such a person, if you ask a question and I don't know the answer, I will directly tell you "I don't know". But I promise you: I know how to find the answer, and I will find it.